I do this with my 09 WR 450. With the rear wheel it needs to be laced slightly to the right to stop the chain from hitting the tyre. You need to cut big scallops into your fork guards to give the front tyre clearance and you may need a longer front brake hose if running a bigger front disk, i also run my hose around the outside of the fork leg to the caliper when in motard setup.
Its a little fiddly to fit the wheels compared to the enduro wheels, with mine on the rear I have to remove the chain guide and rear caliper fit the wheel then re fit the chain guide and caliper.
On the front you have to hold your tongue right and try to feed the caliper onto the adaptor plate there is not much room once the front wheel is fitted. I cover my wheel in tape to protect it whilst doing this. For track I run 14.50 gearing for highway cruising 14. 43.
